RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
N6-methyladenosine (m6A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m6A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly su...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.710964/full |
| _version_ | 1819094046777278464 |
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| author | Peipei Wang Peipei Wang Mengdie Feng Guoqiang Han Rong Yin Yashu Li Shuxin Yao Pengbo Lu Yuhua Wang Haojian Zhang Haojian Zhang Haojian Zhang |
| author_facet | Peipei Wang Peipei Wang Mengdie Feng Guoqiang Han Rong Yin Yashu Li Shuxin Yao Pengbo Lu Yuhua Wang Haojian Zhang Haojian Zhang Haojian Zhang |
| author_sort | Peipei Wang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m6A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m6A biology, and further highlight the roles of m6A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m6A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m6A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m6A in normal hematopoiesis and leukemia pathogenesis. |
| first_indexed | 2024-12-21T23:21:11Z |
| format | Article |
| id | doaj.art-dca8c742d0f44cf9a4cf66307a0c419b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T23:21:11Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-dca8c742d0f44cf9a4cf66307a0c419b2022-12-21T18:46:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.710964710964RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant HematopoiesisPeipei Wang0Peipei Wang1Mengdie Feng2Guoqiang Han3Rong Yin4Yashu Li5Shuxin Yao6Pengbo Lu7Yuhua Wang8Haojian Zhang9Haojian Zhang10Haojian Zhang11The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, ChinaFrontier Science Center for Immunology and Metabolism, School of Medicine, Medical Research Institute, Wuhan University, Wuhan, ChinaRNA Institute, Wuhan University, Wuhan, ChinaN6-methyladenosine (m6A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m6A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m6A biology, and further highlight the roles of m6A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m6A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m6A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m6A in normal hematopoiesis and leukemia pathogenesis.https://www.frontiersin.org/articles/10.3389/fcell.2021.710964/fullRNA m6Ahematopoietic stem cellsleukemia stem cellshematopoiesismyeloid leukemia |
| spellingShingle | Peipei Wang Peipei Wang Mengdie Feng Guoqiang Han Rong Yin Yashu Li Shuxin Yao Pengbo Lu Yuhua Wang Haojian Zhang Haojian Zhang Haojian Zhang RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis Frontiers in Cell and Developmental Biology RNA m6A hematopoietic stem cells leukemia stem cells hematopoiesis myeloid leukemia |
| title | RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis |
| title_full | RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis |
| title_fullStr | RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis |
| title_full_unstemmed | RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis |
| title_short | RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis |
| title_sort | rna m6a modification plays a key role in maintaining stem cell function in normal and malignant hematopoiesis |
| topic | RNA m6A hematopoietic stem cells leukemia stem cells hematopoiesis myeloid leukemia |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.710964/full |
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