Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages

Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages

Varenicline is a widely used and effective drug for smoking cessation. We have previously reported experimental evidence suggesting that varenicline increases the risk of cardiovascular events. Varenicline progresses atherosclerotic plaque formation in apolipoprotein E knockout (ApoE KO) mice. This...

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Bibliographic Details
Main Authors: Mitsuhisa Koga, Yuki Kanaoka, Koshun Inada, Sai Omine, Yasufumi Kataoka, Atsushi Yamauchi
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Varenicline
Hesperidin
Atherosclerosis
Oxidized low-density lipoprotein accumulation
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300207

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http://www.sciencedirect.com/science/article/pii/S1347861320300207

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