Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas

Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas

Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs lower sFlt-1 by suppressing placental renin–angiotensin system (RAS) activity, we studied gene expression and protein...

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Bibliographic Details
Main Authors: Yuan Sun, Lunbo Tan, Rugina I. Neuman, Michelle Broekhuizen, Sam Schoenmakers, Xifeng Lu, A. H. Jan Danser
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pre-eclampsia
renin–angiotensin system
megalin
proton pump inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/14/7407

Internet

https://www.mdpi.com/1422-0067/22/14/7407

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