Tumor Ulceration, Reduced Infiltration of CD8-Lymphocytes, High Neutrophil-to-CD8-Lymphocyte Ratio and Absence of MC Virus are Negative Prognostic Markers for Patients with Merkel Cell Carcinoma

Tumor Ulceration, Reduced Infiltration of CD8-Lymphocytes, High Neutrophil-to-CD8-Lymphocyte Ratio and Absence of MC Virus are Negative Prognostic Markers for Patients with Merkel Cell Carcinoma

(1) Background: Merkel cell carcinoma (MCC) is caused by the Merkel cell polyomavirus and UV radiation. Understanding of the underlying biology is limited, but identification of prognostic markers may lead to better prognostic stratification for the patients. (2) Methods: Ninety patients diagnosed w...

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Bibliographic Details
Main Authors: Simon Naseri, Torben Steiniche, Jeanette Bæhr Georgsen, Rune Thomsen, Morten Ladekarl, Martin Heje, Tine Engberg Damsgaard, Marie Louise Bønnelykke-Behrndtz
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
Merkel cell carcinoma
Merkel cell polyoma virus
tumor microenvironment
CD8 lymphocytes
ulceration
E-cadherin
Online Access:https://www.mdpi.com/2072-6694/12/4/888

Internet

https://www.mdpi.com/2072-6694/12/4/888

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