EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation

EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation

Abstract Background Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resulting in differential gene regulation. However, it remains unknown how PRC2...

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Bibliographic Details
Main Authors: Weipeng Mu, Joshua Starmer, Della Yee, Terry Magnuson
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Epigenetics & Chromatin
Subjects:
Polycomb-group proteins
EZH2
Spermatogenesis
Alternative splicing
Histone methylation
Cell differentiation
Online Access:http://link.springer.com/article/10.1186/s13072-018-0242-9

Internet

http://link.springer.com/article/10.1186/s13072-018-0242-9

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