TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells

TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells

Abstract The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that TERRA contributes to ALT via interacting with the lysine-specific demethylase 1A (LSD1 or KDM1A). We show that LS...

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Bibliographic Details
Main Authors: Meng Xu, Dulmi Senanayaka, Rongwei Zhao, Tafadzwa Chigumira, Astha Tripathi, Jason Tones, Rachel M. Lackner, Anne R. Wondisford, Laurel N. Moneysmith, Alexander Hirschi, Sara Craig, Sahar Alishiri, Roderick J. O’Sullivan, David M. Chenoweth, Nicholas J. Reiter, Huaiying Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46509-z

Internet

https://doi.org/10.1038/s41467-024-46509-z

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