Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo d...

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Bibliographic Details
Main Authors: Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L. Tung, Rosalind F. Hannen, Yasmin R. Mohseni, Cristiano Scotta, Federica M. Marelli-Berg, Robert I. Lechler, Lesley A. Smyth, Gilbert O. Fruhwirth, Giovanna Lombardi
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adoptive cell transfer
cell tracking
human sodium iodide symporter
innate immune cells
lentivirus
multi-modal imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302515

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http://www.sciencedirect.com/science/article/pii/S2329050120302515

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