Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

This paper presents the synthesis of some unique bi-heterocyclic hybrid molecules with a thiazole and an oxadiazole ring. The synthesis was initiated by the conversion of ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) to the corresponding 2-(2-amino-1,3-thiazol-4-yl)acetohydrazide (2) by the reaction...

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Bibliographic Details
Main Authors: Abbasi Muhammad Athar, Ramzan Muhammad Shahid, Aziz-Ur-Rehman, Siddiqui Sabahat Zahra, Hassan Mubashir, Raza Hussain, Shah Syed Adnan Ali, Mirza Bushra, Seo Sung-Yum
Format: Article
Language:English
Published: Serbian Chemical Society 2019-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
1,3-thiazole
1,3,4-oxadiazole
acetylcholinesterase
butyrylcholine-esterase
urease
glucosidase
molecular docking
brine shrimps
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900019A.pdf

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http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900019A.pdf

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