Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns.

Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns.

SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 (TMPRSS2) to facilitate viral-host membrane fusion. ACE2 and TMPRSS2 expression profiles have been analyzed at the genomic, transcrip...

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Bibliographic Details
Main Authors: Ilhan Tomris, Kim M Bouwman, Youri Adolfs, Danny Noack, Roosmarijn van der Woude, Gius Kerster, Sander Herfst, Rogier W Sanders, Marit J van Gils, Geert-Jan Boons, Bart L Haagmans, R Jeroen Pasterkamp, Barry Rockx, Robert P de Vries
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010340

Internet

https://doi.org/10.1371/journal.ppat.1010340

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