Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels.

Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels.

CALHM1 is a plasma membrane voltage-gated Ca2+-permeable ion channel that controls amyloid-β (Aβ) metabolism and is potentially involved in the onset of Alzheimer's disease (AD). Recently, Rubio-Moscardo et al. (PLoS One (2013) 8: e74203) reported the identification of two CALHM1 variants, G330...

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Bibliographic Details
Main Authors: Valérie Vingtdeux, Jessica E Tanis, Pallavi Chandakkar, Haitian Zhao, Ute Dreses-Werringloer, Fabien Campagne, J Kevin Foskett, Philippe Marambaud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4227689?pdf=render

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http://europepmc.org/articles/PMC4227689?pdf=render

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