Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation

Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation

Summary: Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that impact several diseases. We hypothesized that we could gain new insights...

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Bibliographic Details
Main Authors: José Luis Villanueva-Cañas, Narcis Fernandez-Fuentes, Dominik Saul, Robyn Laura Kosinsky, Catherine Teyssier, Malgorzata Ewa Rogalska, Ferran Pegenaute Pérez, Baldomero Oliva, Cedric Notredame, Miguel Beato, Priyanka Sharma
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Molecular biology
Evolutionary biology
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422400806X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422400806X

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