Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering

Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering

Introduction: The growing demand for recombinant proteins in medicine has prompted biopharmaceutical companies to seek ways to maximize the manufacturing process. Despite its known negative impact on cell growth, temperature shift (TS) has emerged as a cost-effective strategy to enhance protein quan...

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Bibliographic Details
Main Authors: Farzaneh Shahabi, Shahriyar Abdoli, Zahra Bazi, Fatemeh Shamsabadi, Ahad Yamchi, Majid Shahbazi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioprocess engineering
mTORC1
CHO cells
thermal shift
HSP90 promoter
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1268048/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1268048/full

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