An <i>Aedes aegypti</i>-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

An <i>Aedes aegypti</i>-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses. The exogenous small interfering (si)RNA (exo-siRNA) pathway is believed to be the main antiviral defense in arthropods, including mosquitoes...

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Bibliographic Details
Main Authors: Christina Scherer, Jack Knowles, Vattipally B. Sreenu, Anthony C. Fredericks, Janina Fuss, Kevin Maringer, Ana Fernandez-Sesma, Andres Merits, Margus Varjak, Alain Kohl, Esther Schnettler
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
RNAi
exo-siRNA pathway
Ago2
Dcr2
knockout cell line
arbovirus replication
Online Access:https://www.mdpi.com/1999-4915/13/6/1066

Internet

https://www.mdpi.com/1999-4915/13/6/1066

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