MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation

Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human malignancies, such as breast cancer. However, their application to other tumor types and intrinsic resistance mechanisms are still unclear. Here, we demonstrate that MYC amplification confers resistance to CDK4/6i in blad...

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Bibliographic Details
Main Authors: Jian Ma, Lei Li, Bohan Ma, Tianjie Liu, Zixi Wang, Qi Ye, Yunhua Peng, Bin Wang, Yule Chen, Shan Xu, Ke Wang, Fabin Dang, Xinyang Wang, Zixuan Zeng, Yanlin Jian, Zhihua Ren, Yizeng Fan, Xudong Li, Jing Liu, Yang Gao, Wenyi Wei
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45796-w

Internet

https://doi.org/10.1038/s41467-024-45796-w

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