Association between lower body temperature and increased tau pathology in cognitively normal older adults

Association between lower body temperature and increased tau pathology in cognitively normal older adults

Background: Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in Alzheimer's Disease (AD). Tau phosphorylation is substantially increased by a small (<1 °C) decrease in temperature within the...

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Bibliographic Details
Main Authors: Esther M. Blessing, Ankit Parekh, Rebecca A. Betensky, James Babb, Natalie Saba, Ludovic Debure, Andrew W. Varga, Indu Ayappa, David M. Rapoport, Tracy A. Butler, Mony J. de Leon, Thomas Wisniewski, Brian J. Lopresti, Ricardo S. Osorio
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Neurobiology of Disease
Subjects:
Tau
Phosphorylation
Body temperature
Aging
Alzheimer's disease
Neurofibrillary tangle
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001401

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http://www.sciencedirect.com/science/article/pii/S0969996122001401

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