B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context

B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context

Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is unknown. B4GALNT3 expresses the enzyme beta-1,...

Full description

Bibliographic Details
Main Authors: Sofia Movérare-Skrtic, Jakob Voelkl, Karin H. Nilsson, Maria Nethander, Trang Thi Doan Luong, Ioana Alesutan, Lei Li, Jianyao Wu, Karin Horkeby, Marie K. Lagerquist, Antti Koskela, Juha Tuukkanen, Jon H. Tobias, Ulf H. Lerner, Petra Henning, Claes Ohlsson
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:EBioMedicine
Subjects:
Osteoporosis
Osteoblasts
Fracture risk
Mendelian randomization
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423001111

Internet

http://www.sciencedirect.com/science/article/pii/S2352396423001111

Similar Items