TGFβ level in healthy and children with Marfan syndrome—effective reduction under sartan therapy

TGFβ level in healthy and children with Marfan syndrome—effective reduction under sartan therapy

IntroductionTransforming growth factor β (TGFβ) metabolism plays an important role in the pathogenesis of Marfan syndrome (MFS). Accordingly, drug therapy uses TGFβ receptor blockade to slow down the cardiovascular manifestations, above all aortic root dilatation. Angiotensin II type 1 receptor bloc...

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Bibliographic Details
Main Authors: Veronika C. Stark, Jakob Olfe, Daniel Diaz-Gil, Yskert von Kodolitsch, Rainer Kozlik-Feldmann, Johannes Reincke, Maria Stark, Peter Wiegand, Tanja Zeller, Thomas S. Mir
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pediatrics
Subjects:
Marfan
TGFβ
sartan
connective tissue disorder
genetic aortic disease
aortic dilatation
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2024.1276215/full

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https://www.frontiersin.org/articles/10.3389/fped.2024.1276215/full

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