Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium<sup>®</sup>) is an establi...

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Bibliographic Details
Main Authors: Elham Hakimizadeh, Mohammad Zamanian, Lydia Giménez-Llort, Clara Sciorati, Marjan Nikbakhtzadeh, Małgorzata Kujawska, Ayat Kaeidi, Jalal Hassanshahi, Iman Fatemi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
aging
antioxidant activity
calcium dobesilate
Doxium
D-galactose
mice
Online Access:https://www.mdpi.com/2076-3921/10/5/649

Internet

https://www.mdpi.com/2076-3921/10/5/649

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