Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models

Abstract Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing radiation (RT) and ET are used for the treatment of women with ER+ breast cancer, the most effective sequencing of therapy and the effect of ET on...

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Bibliographic Details
Main Authors: Anna R. Michmerhuizen, Lynn M. Lerner, Andrea M. Pesch, Connor Ward, Rachel Schwartz, Kari Wilder-Romans, Meilan Liu, Charles Nino, Kassidy Jungles, Ruth Azaria, Alexa Jelley, Nicole Zambrana Garcia, Alexis Harold, Amanda Zhang, Bryan Wharram, Daniel F. Hayes, James M. Rae, Lori J. Pierce, Corey W. Speers
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00397-y