Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics
Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulatory interactions known as the pluripotency gene reg...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-05-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506118300564 |
| _version_ | 1818554342696812544 |
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| author | Dmitri Papatsenko Avinash Waghray Ihor R. Lemischka |
| author_facet | Dmitri Papatsenko Avinash Waghray Ihor R. Lemischka |
| author_sort | Dmitri Papatsenko |
| collection | DOAJ |
| description | Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulatory interactions known as the pluripotency gene regulatory network (PGRN). Despite extensive investigation of the network, the exact order of regulatory links and many structural features of the network are still missing. Analysis of published data and literature reveals numerous PGRN components regulating each other in a mutual fashion, thus creating multiple regulatory feedback control circuits. Here we consider possible organizational features of PGRN and describe examples representing known feedback control loops in the context of mouse ESCs. We discuss how the feedback control interactions can contribute to learning behavior and dynamic responses of pluripotency gene network to changing environments. Keywords: Embryonic stem cells, Gene networks, Feedback control, Cellular memory |
| first_indexed | 2024-12-12T09:38:08Z |
| format | Article |
| id | doaj.art-dcd61e01223d4604b5b0dc905f9b1dc8 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-12T09:38:08Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-dcd61e01223d4604b5b0dc905f9b1dc82022-12-22T00:28:40ZengElsevierStem Cell Research1873-50612018-05-0129180188Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigeneticsDmitri Papatsenko0Avinash Waghray1Ihor R. Lemischka2Skolkovo Institute of Sciences and Technologies, Skolkovo Innovation Center, Building 3, Moscow 143026, Russia; Department of Regenerative and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA; Black Family Stem Cell Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USAMassachusetts General Hospital, Center for Regenerative Medicine, 185 Cambridge St. CPZN 4.240, Boston, MA 02114, , USA; Corresponding author.Department of Regenerative and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA; Black Family Stem Cell Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Pharmacology and System Therapeutics, Mount Sinai School of Medicine, Systems Biology Center New York, One Gustave L. Levy Place, New York, NY 10029, USAEmbryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulatory interactions known as the pluripotency gene regulatory network (PGRN). Despite extensive investigation of the network, the exact order of regulatory links and many structural features of the network are still missing. Analysis of published data and literature reveals numerous PGRN components regulating each other in a mutual fashion, thus creating multiple regulatory feedback control circuits. Here we consider possible organizational features of PGRN and describe examples representing known feedback control loops in the context of mouse ESCs. We discuss how the feedback control interactions can contribute to learning behavior and dynamic responses of pluripotency gene network to changing environments. Keywords: Embryonic stem cells, Gene networks, Feedback control, Cellular memoryhttp://www.sciencedirect.com/science/article/pii/S1873506118300564 |
| spellingShingle | Dmitri Papatsenko Avinash Waghray Ihor R. Lemischka Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics Stem Cell Research |
| title | Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics |
| title_full | Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics |
| title_fullStr | Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics |
| title_full_unstemmed | Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics |
| title_short | Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics |
| title_sort | feedback control of pluripotency in embryonic stem cells signaling transcription and epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S1873506118300564 |
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