CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation

CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation

Background: Medullary Thyroid Cancer (MTC) is a very aggressive type of thyroid carcinoma. Mutation in RET proto-oncogene is demonstrated in MTC development. We aimed to knock-out of RET-oncogene using CRISPR/Cas9 genome editing method in MTC cell-lines. Methods: This research was conducted in S...

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Bibliographic Details
Main Authors: Marjan Zarif-Yeganeh, Dariush D Farhud, Azam Rahimpour, Sara Sheikholeslami, Setareh Shivaei, Mehdi Hedayati
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2022-05-01
Series:Iranian Journal of Public Health
Subjects:
CRISPR/Cas9
Gene editing
Medullary thyroid cancer
RET gene
TT cell-line
MZ-CRC-1 cell-line
Online Access:https://ijph.tums.ac.ir/index.php/ijph/article/view/28675

Internet

https://ijph.tums.ac.ir/index.php/ijph/article/view/28675

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