Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H+-ATPase.
Weibel-Palade bodies (WPB) are unique secretory granules of endothelial cells that store the procoagulant von-Willebrand factor (VWF) in a highly compacted form. Upon exocytosis the densely packed VWF unfurls into long strands that expose binding sites for circulating platelets and thereby initiate...
| Hoofdauteurs: | , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2022-01-01
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| Reeks: | PLoS ONE |
| Online toegang: | https://doi.org/10.1371/journal.pone.0270299 |