Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals

Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals

Ibuprofen, a non-steroidal, anti-inflammatory drug, modulates inflammation but may also have neuroprotective effects on brain health that are poorly understood. Astrocyte-enriched extracellular vesicles (AEEVs) facilitate cell-to-cell communication and – among other functions - regulate inflammation...

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Bibliographic Details
Main Authors: Kaiping Burrows, Leandra K. Figueroa-Hall, Ahlam M. Alarbi, Jennifer L. Stewart, Rayus Kuplicki, Chibing Tan, Bethany N. Hannafon, Rajagopal Ramesh, Jonathan Savitz, Sahib Khalsa, T. Kent Teague, Victoria B. Risbrough, Martin P. Paulus
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Astrocyte-enriched extracellular vesicles
miR-23b
Ibuprofen
Inflammation
Reward processing
Monetary incentive delay task
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354622001727

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http://www.sciencedirect.com/science/article/pii/S2666354622001727

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