Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

Streptococcus pyogenes is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial nucleic acids, especially bacterial RNA, have recently been recognized as a major group of pathogen-associated molecular pat...

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Bibliographic Details
Main Authors: Anna Hafner, Ulrike Kolbe, Isabel Freund, Virginia Castiglia, Pavel Kovarik, Tanja Poth, Franziska Herster, Markus A. Weigand, Alexander N. R. Weber, Alexander H. Dalpke, Tatjana Eigenbrod
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pyogenes
bacterial RNA
nucleic acids
TLR13
UNC93B1
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00198/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00198/full

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