Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

HIV-1 Reverse Transcriptase (HIV-1 RT) has been the target of numerous approved anti-AIDS drugs that are key components of Highly Active Anti-Retroviral Therapies (HAART). It remains the target of extensive structural studies that continue unabated for almost twenty years. The crystal structures of...

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Bibliographic Details
Main Authors: Stefan G. Sarafianos, Eleftherios Michailidis, Karen A. Kirby, Bruno Marchand, Kamalendra Singh
Format: Article
Language:English
Published: MDPI AG 2010-02-01
Series:Viruses
Subjects:
HIV-1 reverse transcriptase
nucleoside RT inhibitors
non-nucleoside RT inhibitors
translocation defective RT inhibitors
drug resistance
excision
Online Access:http://www.mdpi.com/1999-4915/2/2/606/

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http://www.mdpi.com/1999-4915/2/2/606/

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