The <i>Trypanosoma cruzi</i> TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

The <i>Trypanosoma cruzi</i> TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues

Among the scarce validated drug targets against Chagas disease (CD), caused by <i>Trypanosoma cruzi</i>, the parasite’s nucleoside salvage system has recently attracted considerable attention. Although the trypanocidal activity of tubercidin (7-deazapurine) has long been known, the ident...

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Bibliographic Details
Main Authors: Mustafa M. Aldfer, Ibrahim A. Alfayez, Hamza A. A. Elati, Nilanjana Gayen, Ehab Kotb Elmahallawy, Ana Milena Murillo, Sabrina Marsiccobetre, Serge Van Calenbergh, Ariel M. Silber, Harry P. de Koning
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
<i>Trypanosoma cruzi</i>
nucleoside transporter
pyrimidine transporter
thymidine
TcrNT2
tubercidin analog
Online Access:https://www.mdpi.com/1420-3049/27/22/8045

Internet

https://www.mdpi.com/1420-3049/27/22/8045

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