Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle.

Adeno-associated viral vector-mediated transgene expression is independent of DNA methylation in primate liver and skeletal muscle.

Recombinant adeno-associated viral (rAAV) vectors can support long-term transgene expression in quiescent tissues. Intramuscular (i.m.) administration of a single-stranded AAV vector (ssAAV) in the nonhuman primate (NHP) results in a peak protein level at 2-3 months, followed by a decrease over seve...

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Bibliographic Details
Main Authors: Adrien Léger, Caroline Le Guiner, Michael L Nickerson, Kate McGee Im, Nicolas Ferry, Philippe Moullier, Richard O Snyder, Magalie Penaud-Budloo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3110818?pdf=render

Internet

http://europepmc.org/articles/PMC3110818?pdf=render

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