Double heterozygous pathogenic variants prevalence in a cohort of patients with hereditary breast cancer

Double heterozygous pathogenic variants prevalence in a cohort of patients with hereditary breast cancer

Hereditary breast cancer (BC) corresponds to 5% of all BC and a larger parcel of early-onset disease. The incorporation of next-generation sequencing (NGS) techniques reduced the cost of molecular testing and allowed the inclusion of additional cancer predisposition genes in panels that are more com...

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Bibliographic Details
Main Authors: Thais Baccili Cury Megid, Mateus C. Barros-Filho, Janina Pontes Pisani, Maria Isabel Achatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
breast cancer
double heterozygous variants
germline panels
hereditary breast cancer
NGS
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.873395/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.873395/full

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