Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen

Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen

Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV) viruses, are mosquito-borne pathogens that present a major risk to global public health. To identify host factors that promote flavivirus replication, we performed a genome-wide gain-of-function cDNA screen for...

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Bibliographic Details
Main Authors: Evgeniya Petrova, Ségolène Gracias, Guillaume Beauclair, Frédéric Tangy, Nolwenn Jouvenet
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Viruses
Subjects:
Flavivirus
West Nile virus
Yellow fever virus
Zika virus
Host-pathogen interactions
Virus replication
Genome-wide gain-of-function screen
Oligosaccharyltransferase complex
Ribosomal proteins
Online Access:http://www.mdpi.com/1999-4915/11/1/68

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http://www.mdpi.com/1999-4915/11/1/68

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