Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline. Reduced mitochondrial function may be an early event that compromises synaptic integrity and neurotransmission in vulnerable brain regions during physiological and pathological aging. Thus, we aimed to measur...

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Bibliographic Details
Main Authors: César Espino de la Fuente-Muñoz, Mónica Rosas-Lemus, Perla Moreno-Castilla, Federico Bermúdez-Rattoni, Salvador Uribe-Carvajal, Clorinda Arias
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
synaptic mitochondria
brain aging
synaptosomes
mitochondrial dynamics
amyloid-β protein
tau
Online Access:https://www.mdpi.com/1422-0067/21/22/8727

Internet

https://www.mdpi.com/1422-0067/21/22/8727

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