Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice
Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline. Reduced mitochondrial function may be an early event that compromises synaptic integrity and neurotransmission in vulnerable brain regions during physiological and pathological aging. Thus, we aimed to measur...
Main Authors: | César Espino de la Fuente-Muñoz, Mónica Rosas-Lemus, Perla Moreno-Castilla, Federico Bermúdez-Rattoni, Salvador Uribe-Carvajal, Clorinda Arias |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/22/8727 |
Similar Items
-
Dendrobine Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline in 3 × Tg-AD Mice
by: Wei Zhang, et al.
Published: (2024-02-01) -
Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats
by: Dragana Filipović, et al.
Published: (2022-12-01) -
Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction
by: Giacomo Siano, et al.
Published: (2021-09-01) -
APP family member dimeric complexes are formed predominantly in synaptic compartments
by: Sandra Schilling, et al.
Published: (2023-08-01) -
Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease
by: Laura Martínez-Drudis, et al.
Published: (2022-10-01)