Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway

Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway

Kinsenoside (KD) exhibits anti-inflammatory and immunosuppressive effects. Dendritic cells (DCs) are critical regulators of the pathologic inflammatory milieu in liver fibrosis (LF). Herein, we explored whether and how KD repressed development of LF via DC regulation and verified the pathway involve...

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Bibliographic Details
Main Authors: Ming Xiang, Tingting Liu, Cheng Tian, Kun Ma, Jing Gou, Rongrong Huang, Senlin Li, Qing Li, Chuanrui Xu, Lei Li, Chih-Hao Lee, Yonghui Zhang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Liver fibro-inflammation
Kinsenoside
Dendritic cell
PI3K-AKT-FoxO1 axis
Programmed cell death ligand 1
Interleukin-12
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000378

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http://www.sciencedirect.com/science/article/pii/S1043661822000378

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