Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells

Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells

Mesangial cells are the major extracellular matrix (ECM)-producing cells in the kidney glomerulus and, when exposed to elevated glucose levels, they up-regulate assembly of fibronectin (FN) and other ECM proteins. Increases in glucose concentration are known to alter gene expression; here we investi...

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Bibliographic Details
Main Authors: Maria E. Vega, John B. Finlay, Mansi Vasishtha, Jean E. Schwarzbauer
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Matrix Biology Plus
Subjects:
Diabetic nephropathy
Extracellular matrix
Gene expression
Tenascin-C
Fibronectin
Alternative splicing
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028520300296

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http://www.sciencedirect.com/science/article/pii/S2590028520300296

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