Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

Abstract Background The human gut microbiome performs important functions in human health and disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of primary bile acids and their subsequent deconjugation and transformation by the gut microbiome. To understand these sy...

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Bibliographic Details
Main Authors: Almut Heinken, Dmitry A. Ravcheev, Federico Baldini, Laurent Heirendt, Ronan M. T. Fleming, Ines Thiele
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Microbiome
Subjects:
Gut microbiome
Bile acids
Host-microbe interactions
Metabolism
Genome-scale reconstruction
Constraint-based modeling
Online Access:http://link.springer.com/article/10.1186/s40168-019-0689-3

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http://link.springer.com/article/10.1186/s40168-019-0689-3

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