o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

AbstractToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor) domains and the downstream adaptor proteins...

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Bibliographic Details
Main Authors: Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Covalent modification
o-vanillin
MyD88 adaptor-like (MAL)
nuclear magnetic resonance (NMR)
Toll-like receptor (TLR)
Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP)
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2313055

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2024.2313055

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