KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.

KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.

Krüppel-associated box domain-zinc finger proteins (KRAB-ZFPs) are tetrapod-specific transcriptional repressors encoded in the hundreds by the human genome. In order to explore their as yet ill-defined impact on gene expression, we developed an ectopic repressor assay, allowing the study of KRAB-med...

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Bibliographic Details
Main Authors: Anna C Groner, Sylvain Meylan, Angela Ciuffi, Nadine Zangger, Giovanna Ambrosini, Nicolas Dénervaud, Philipp Bucher, Didier Trono
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2832679?pdf=render

Internet

http://europepmc.org/articles/PMC2832679?pdf=render

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