Collagen‐Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Collagen‐Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Background Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that regulates biosynthesis and secretion of procollagen in hea...

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Bibliographic Details
Main Authors: Andrii Puzyrenko, Elizabeth R. Jacobs, Nathan Padilla, Adam Devine, Michael Aljadah, Benjamin N. Gantner, Amy Y. Pan, Shuping Lai, Qiang Dai, Jason C. Rubenstein, Paula E. North, Pippa M. Simpson, Rodney E. Willoughby, Caitlin C. O'Meara, Michael A. Flinn, John W. Lough, El‐Sayed H. Ibrahim, Ze Zheng, Yunguang Sun, Juan Felix, Bryan C. Hunt, Gracious Ross, Hallgeir Rui, Ivor J. Benjamin
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac fibrosis
COVID‐19
endoplasmic reticulum
heat shock proteins
human autopsy
stress
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.027990

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https://www.ahajournals.org/doi/10.1161/JAHA.122.027990

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