Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias

Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias

Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-) sulfides) have been shown t...

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Bibliographic Details
Main Authors: Tyler H. Reekes, Christina R. Ledbetter, J. Steven Alexander, Karen Y. Stokes, Sibile Pardue, Mohammad Alfrad Nobel Bhuiyan, James C. Patterson, Katelyn T. Lofton, Christopher G. Kevil, Elizabeth A. Disbrow
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Hydrogen sulfide
Bound sulfides
Acid labile sulfides
Free sulfides
Microvascular disease
Cortical thickness
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000344

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http://www.sciencedirect.com/science/article/pii/S2213231723000344

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