Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias
Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-) sulfides) have been shown t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231723000344 |
| _version_ | 1827950729908715520 |
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| author | Tyler H. Reekes Christina R. Ledbetter J. Steven Alexander Karen Y. Stokes Sibile Pardue Mohammad Alfrad Nobel Bhuiyan James C. Patterson Katelyn T. Lofton Christopher G. Kevil Elizabeth A. Disbrow |
| author_facet | Tyler H. Reekes Christina R. Ledbetter J. Steven Alexander Karen Y. Stokes Sibile Pardue Mohammad Alfrad Nobel Bhuiyan James C. Patterson Katelyn T. Lofton Christopher G. Kevil Elizabeth A. Disbrow |
| author_sort | Tyler H. Reekes |
| collection | DOAJ |
| description | Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-) sulfides) have been shown to modulate both vascular and neuronal homeostasis. We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and measures of microvascular disease in ADRD. Here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased grey matter volume, while increased acid labile sulfides were associated with decreased white matter integrity and greater ventricular volume. These findings are consistent with alterations in sulfide metabolism in ADRD which may represent maladaptive responses to oxidative stress. |
| first_indexed | 2024-04-09T13:31:15Z |
| format | Article |
| id | doaj.art-dd00027e0083417aae6feee59297e0b3 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-09T13:31:15Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-dd00027e0083417aae6feee59297e0b32023-05-10T04:18:56ZengElsevierRedox Biology2213-23172023-06-0162102633Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementiasTyler H. Reekes0Christina R. Ledbetter1J. Steven Alexander2Karen Y. Stokes3Sibile Pardue4Mohammad Alfrad Nobel Bhuiyan5James C. Patterson6Katelyn T. Lofton7Christopher G. Kevil8Elizabeth A. Disbrow9Department of Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, United States; Center for Brain Health, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Department of Neurosurgery, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Center for Cardiovascular Diseases and Sciences, LSU Health Shreveport, United States; Department of Neurology, LSU Health Shreveport, United States; Department of Molecular and Cellular Physiology, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Center for Cardiovascular Diseases and Sciences, LSU Health Shreveport, United States; Department of Molecular and Cellular Physiology, LSU Health Shreveport, United StatesCenter for Cardiovascular Diseases and Sciences, LSU Health Shreveport, United States; Department of Pathology and Translational Pathobiology, LSU Health Shreveport, United StatesDepartment of Internal Medicine, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Department of Psychiatry and Behavioral Medicine, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Department of Neurology, LSU Health Shreveport, United States; Department of Psychiatry and Behavioral Medicine, LSU Health Shreveport, United StatesCenter for Brain Health, LSU Health Shreveport, United States; Center for Cardiovascular Diseases and Sciences, LSU Health Shreveport, United States; Department of Pathology and Translational Pathobiology, LSU Health Shreveport, United States; Corresponding author. LSU Health Sciences Center, Shreveport, BRI 1-29, 1501 Kings Highway, Shreveport, LA 71130-3932, United States.Department of Pharmacology, Toxicology & Neuroscience, LSU Health Shreveport, United States; Center for Brain Health, LSU Health Shreveport, United States; Center for Cardiovascular Diseases and Sciences, LSU Health Shreveport, United States; Department of Neurology, LSU Health Shreveport, United States; Corresponding author. Dept. of Neurology LSU Health Sciences Center, Shreveport Center for Brain Health, PO Box 33932, Shreveport, LA 71130-3932, United States.Emerging evidence indicates that vascular stress is an important contributor to the pathophysiology of Alzheimer's disease and related dementias (ADRD). Hydrogen sulfide (H2S) and its metabolites (acid-labile (e.g., iron-sulfur clusters) and bound (e.g., per-, poly-) sulfides) have been shown to modulate both vascular and neuronal homeostasis. We recently reported that elevated plasma sulfides were associated with cognitive dysfunction and measures of microvascular disease in ADRD. Here we extend our previous work to show associations between elevated sulfides and magnetic resonance-based metrics of brain atrophy and white matter integrity. Elevated bound sulfides were associated with decreased grey matter volume, while increased acid labile sulfides were associated with decreased white matter integrity and greater ventricular volume. These findings are consistent with alterations in sulfide metabolism in ADRD which may represent maladaptive responses to oxidative stress.http://www.sciencedirect.com/science/article/pii/S2213231723000344Hydrogen sulfideBound sulfidesAcid labile sulfidesFree sulfidesMicrovascular diseaseCortical thickness |
| spellingShingle | Tyler H. Reekes Christina R. Ledbetter J. Steven Alexander Karen Y. Stokes Sibile Pardue Mohammad Alfrad Nobel Bhuiyan James C. Patterson Katelyn T. Lofton Christopher G. Kevil Elizabeth A. Disbrow Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias Redox Biology Hydrogen sulfide Bound sulfides Acid labile sulfides Free sulfides Microvascular disease Cortical thickness |
| title | Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias |
| title_full | Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias |
| title_fullStr | Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias |
| title_full_unstemmed | Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias |
| title_short | Elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human Alzheimer's disease and related dementias |
| title_sort | elevated plasma sulfides are associated with cognitive dysfunction and brain atrophy in human alzheimer s disease and related dementias |
| topic | Hydrogen sulfide Bound sulfides Acid labile sulfides Free sulfides Microvascular disease Cortical thickness |
| url | http://www.sciencedirect.com/science/article/pii/S2213231723000344 |
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