Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC

Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC

Abstract Background Both autophagy and glycolysis are essential for pancreatic ductal adenocarcinoma (PDAC) survival due to desmoplasia. We investigated whether targeting a hub gene which participates in both processes could be an efficient strategy for PDAC treatment. Methods The expression pattern...

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Bibliographic Details
Main Authors: Yongsheng Jiang, Lijie Han, Meilin Xue, Ting Wang, Youwei Zhu, Cheng Xiong, Minmin Shi, Hongzhe Li, Wangxi Hai, Yanmiao Huo, Baiyong Shen, Lingxi Jiang, Hao Chen
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Clinical and Translational Medicine
Subjects:
autophagy
biomarker
cystatin B
cystatin C
cathepsin B
glycolysis
Online Access:https://doi.org/10.1002/ctm2.1126

Internet

https://doi.org/10.1002/ctm2.1126

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