Multimodal assessment of the GABA system in patients with fragile-X syndrome and neurofibromatosis of type 1

Multimodal assessment of the GABA system in patients with fragile-X syndrome and neurofibromatosis of type 1

Fragile-X syndrome (FXS) and Neurofibromatosis of type 1 (NF-1) are two monogenic disorders sharing neurobehavioral symptoms and pathophysiological mechanisms. Namely, preclinical models of both conditions show overactivity of the mTOR signaling pathway as well as GABAergic alterations. However, des...

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Bibliographic Details
Main Authors: Angelina Lacroix, Mélodie Proteau-Lemieux, Samantha Côté, Jamie Near, Steve C.N. Hui, Richard A.E. Edden, Sarah Lippé, Artuela Çaku, François Corbin, Jean-François Lepage
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Disease
Subjects:
Neurodevelopmental disorder
MRS
TMS
glutamate
brain
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612200273X

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http://www.sciencedirect.com/science/article/pii/S096999612200273X

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