Porcine reproductive and respiratory syndrome virus non-structural protein 4 cleaves guanylate-binding protein 1 via its cysteine proteinase activity to antagonize GBP1 antiviral effect

Porcine reproductive and respiratory syndrome virus non-structural protein 4 cleaves guanylate-binding protein 1 via its cysteine proteinase activity to antagonize GBP1 antiviral effect

Abstract Porcine reproductive and respiratory syndrome (PRRS) is a highly infectious disease caused by PRRS virus (PRRSV) that causes great economic losses to the swine industry worldwide. PRRSV has been recognized to modulate the host antiviral interferon (IFN) response and downstream interferon-st...

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Bibliographic Details
Main Authors: Hong Duan, Haoxin Dong, Shuya Wu, Jiahui Ren, Mingfang Zhang, Chuangwei Chen, Yongkun Du, Gaiping Zhang, Angke Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Veterinary Research
Subjects:
PRRSV
GBP1
GTPase activity
nsp4 protein
cleavage effect
Online Access:https://doi.org/10.1186/s13567-022-01071-8

Internet

https://doi.org/10.1186/s13567-022-01071-8

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