The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

Abstract Background Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT which increases the storage of triglycerides (TG) in the lipid droplets (LD). Adipogenesis pathways as well as the...

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Bibliographic Details
Main Authors: S. de Frutos, M. Griera, M. Hatem-Vaquero, S. Campillo, E. Gutiérrez-Calabres, D. García-Ayuso, M. Pardo, L. Calleros, M. Rodríguez-Puyol, D. Rodríguez-Puyol
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Cell & Bioscience
Subjects:
Tirofiban
Integrin-beta1
Integrin-linked kinase
AKT
Adipogenesis
Obesity
Online Access:https://doi.org/10.1186/s13578-022-00746-1

Internet

https://doi.org/10.1186/s13578-022-00746-1

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