Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma

Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (<i>PTCH1</i>) are associated with lung function abnormalities in the general population. It has also been shown that sonic hedgehog (SHH), an important ligand for PTCH1, is upregulated in the airway epi...

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Bibliographic Details
Main Authors: Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
hedgehog signaling
asthma
TGFβ
airway remodeling
inflammation
Online Access:https://www.mdpi.com/2073-4409/11/19/3016

Internet

https://www.mdpi.com/2073-4409/11/19/3016

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