Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice

Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice

Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitization and associated diseases has increased in the...

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Bibliographic Details
Main Authors: David L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. Kulkarni, Michael K. Longmire, Ana M. Jaramillo, Rosha P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. Lei, David P. Huston, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
toll-like receptors
allergic asthma
allergen immunotherapy
innate immunity
lung epithelial cells
allergen tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.833380/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.833380/full

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