Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology

Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology

Sleep-related hypermotor epilepsy (SHE) is characterized by hyperkinetic focal seizures, mainly arising in the neocortex during non-rapid eye movements (NREM) sleep. The familial form is autosomal dominant SHE (ADSHE), which can be caused by mutations in genes encoding subunits of the neuronal nicot...

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Bibliographic Details
Main Authors: Andrea Becchetti, Laura Clara Grandi, Giulia Colombo, Simone Meneghini, Alida Amadeo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Brain Sciences
Subjects:
autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)
autosomal dominant sleep-related hypermotor epilepsy (ADSHE)
antiepileptic
cholinergic receptor nicotinic alpha 2 subunit (CHRNA2)
cholinergic receptor nicotinic alpha 4 subunit (CHRNA4)
cholinergic receptor nicotinic beta 2 subunit (CHRNB2)
Online Access:https://www.mdpi.com/2076-3425/10/12/907

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https://www.mdpi.com/2076-3425/10/12/907

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