cLD: Rare-variant linkage disequilibrium between genomic regions identifies novel genomic interactions.

cLD: Rare-variant linkage disequilibrium between genomic regions identifies novel genomic interactions.

Linkage disequilibrium (LD) is a fundamental concept in genetics; critical for studying genetic associations and molecular evolution. However, LD measurements are only reliable for common genetic variants, leaving low-frequency variants unanalyzed. In this work, we introduce cumulative LD (cLD), a s...

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Bibliographic Details
Main Authors: Dinghao Wang, Deshan Perera, Jingni He, Chen Cao, Pathum Kossinna, Qing Li, William Zhang, Xingyi Guo, Alexander Platt, Jingjing Wu, Qingrun Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011074

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https://doi.org/10.1371/journal.pgen.1011074

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