Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Bibliographic Details
Main Authors: Ayan Rajgarhia, Kameshwar R. Ayasolla, Nahla Zaghloul, Jorge M. Lopez Da Re, Edmund J. Miller, Mohamed Ahmed
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypxoia
cardiac fibrosis
EC-SOD
methylation
RASSF1A
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.669975/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.669975/full

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