Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer

Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer

Abstract Platinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, and little is known about how the acquisition of PT-resistance mediates the increased spreading capab...

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Bibliographic Details
Main Authors: Alice Gambelli, Anna Nespolo, Gian Luca Rampioni Vinciguerra, Eliana Pivetta, Ilenia Pellarin, Milena S Nicoloso, Chiara Scapin, Linda Stefenatti, Ilenia Segatto, Andrea Favero, Sara D’Andrea, Maria Teresa Mucignat, Michele Bartoletti, Emilio Lucia, Monica Schiappacassi, Paola Spessotto, Vincenzo Canzonieri, Giorgio Giorda, Fabio Puglisi, Andrea Vecchione, Barbara Belletti, Maura Sonego, Gustavo Baldassarre
Format: Article
Language:English
Published: Springer Nature 2024-04-01
Series:EMBO Molecular Medicine
Subjects:
Ovarian Cancer
Metastasis
Integrin
chemoresistance
Online Access:https://doi.org/10.1038/s44321-024-00069-3

Internet

https://doi.org/10.1038/s44321-024-00069-3

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