Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor n...
| Hlavní autoři: | , , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Taylor & Francis Group
2018-05-01
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| Edice: | Molecular & Cellular Oncology |
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| On-line přístup: | http://dx.doi.org/10.1080/23723556.2017.1327005 |
| Shrnutí: | Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1. |
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| ISSN: | 2372-3556 |